Herein, we report a simple green synthesis of silver nanoparticles (Ag NPs) by the reduction of aqueous silver salt solution using leaf broth of Eucalyptus camaldulensis. The profile of synthesized silver nanoparticles was evaluated by using UV-visible spectrophotometer, X-ray diffractometer, atomic force microscope, energy-dispersive X-ray spectroscope and scanning electron microscope. Surface plasmon resonance peak of silver nanoparticles appeared at 425 nm in UV-vis spectra of silver nanoparticles. XRD studies clearly confirmed the crystalline nature of the synthesized nanoparticles. The EDX analysis disclosed the arranged inorganic composition of the synthesized Ag NPs. Atomic force microscopy investigation revealed 3D surface profile of nanoparticles. From the SEM images, the silver nanoparticles were found to be more or less spherical with an average diameter range of 110-250 nanometers.

Este trabalho apresenta a síntese de uma série de derivados da 2-fenetidina N-substituídos. Primeiro, a reação da 2-fenetidina (1) com cloreto de benzenossulfonila (2) conduziu à N-(2-etoxifenil)benzenossulfonamida (3) que, após tratamento com hidreto de sódio e haletos de alquila (4a-g), originou novas sulfonamidas (5a-g). Em segundo lugar, a reação da fenetidina com cloreto de benzoíla (6) e cloreto de acetila (8) conduziu, respectivamente, à N-benzoilfenetidina (7) e N-acetilfenetidina (9). A caracterização destes derivados fez-se por IV, ¹H-RMN e EM-IE. Procedeu-se à avaliação da atividade inibidora destes compostos em relação às enzimas acetilcolinesterase, butirilcolinesterase e lipoxigenase. No entanto, apenas revelaram atividade inibidora da butirilcolinesterase.

This manuscript reports the synthesis of a series of N-substituted derivatives of 2-phenitidine. First, the reaction of 2-phenitidine (1) with benzene sulfonyl chloride (2) yielded N-(2-ethoxyphenyl) benzenesulfonamide (3), which further on treatment with sodium hydride and alkyl halides (4a-g) furnished into new sulfonamides (5a-g). Second, the phenitidine reacted with benzoyl chloride (6) and acetyl chloride (8) to yield the reported N-benzoyl phenitidine (7) and N-acetyl phenitidine (9), respectively. These derivatives were characterized by infrared spectroscopy, ¹H-NMR, and EI-MS, and then screened against acetylcholinesterase, butylcholinesterase, and lipoxygenase enzyme, and were found to be potent inhibitors of butyrylcholinesterase alone.